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Code Name Synonym
ET-077 Mpa(Trt) 3-trityl-mercaptopropionic acid
CAS 27144-18-9 /upload/more_svg/small/small_ET-077.svg
Formula C22H20O2S
MW 348.5
Purity >99%
Storage +2 ... +8 °C
Code Name Synonym
ET-082 4-[(Boc)2-Guanidino]phenylacetic acid (Boc)2-4-GPAc-OH // 4-[Bis(tert-butyloxycarbonyl)-guanidino]phenylacetic acid
CAS 1263045-12-0 /upload/svg/small/small_et-082.svg
Formula C19H27N3O6
MW 393.4
Purity >98%
Storage +2 ... +8 °C
Code Name Synonym
ET-081 4-trans-(Boc2-Guanidino)metilcyclohexane carboxylic acid (Boc)2-4-trans-Gmc-OH
CAS 1263047-40-0 /upload/more_svg/small/small_ET-081.svg
Formula C19H33N3O6
MW 399.5
Purity >98%
Storage +2 ... +8 °C
Code Name Synonym
ET-083 4-cis-[(Boc)2-Guanidino]cyclohexane carboxylic acid 4-cis-[Bis(tert-butyloxycarbonyl)-guanidino]cyclohexane carboxylic acid
CAS 1263045-22-2 /upload/more_svg/small/small_ET-083.svg
Formula C18H31N3O6
MW 385.5
Purity >98%
Storage +2 ... +8 °C
Code Name Synonym
ET-153 4-(azidomethyl)benzoic acid 4-azidomethylbenzoic Acid
CAS 79584-03-5 /upload/more_svg/small/small_et-153.svg
Formula C8H7N3O2
MW 177.2
Purity >98%
Storage +2 ... +8 °C
Note 4-(azidomethyl)benzoic acid is used in azide-alkyne ligation chemistry using click-chemistry. JACS (2004), 126(29), 8862-8863. DOI:10.1021/ja049684r;  DOI:10.1002/anie.201206281; Chemistry - A European Journal (2018), 24(7), 1619-1630. DOI:10.1002/chem.201704179.
Code Name Synonym
ET-162 Mal(Br2)-AEEA 3,4-dibrommaleimido-AEEA // dibrommaleimido AEEA // DB-AEEA // DBM-AEEA // 3,4-dibrommaleimido 8-amino-3,6-dioxaoctanoic acid // 3,4-dibrommaleimido O2Oc // 3,4-dibrommaleimido Ado // 3,4-dibrommaleimido Adoa // 2‐{2‐[2‐(3,4‐dibromo‐2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)ethoxy]ethoxy}acetic acid
CAS n/a /upload/small/small_et-162.svg
Formula C10H11Br2NO6
MW 401
Purity >98%
Storage +2 ... +8 °C
Note Mal(Br2)-AEEA is used as a hydrophylic bio-conjugation reagent for antibody-drug-conjugate synthesis. The di-bromo maleimide is a novel conjugation tool that addresses the retro-Michael instability of simple thiosuccinimide linkage. Baker et al Organic & Biomolecular Chemistry (2014), 12(37), 7261-7269. DOI:10.1039/C4OB01550A; Jackson et al Molecular Pharmaceutics (2015), 12(11), 3986-3998. DOI:10.1021/acs.molpharmaceut.5b00432; Baker et al Organic & Biomolecular Chemistry (2017), 15(14), 2947-2952. DOI:10.1039/C7OB00220C.
Code Name Synonym
ET-075 Mal-AMCHC 4-(maleimidomethyl)cyclohexane-1-carboxylic acid // trans-4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid
CAS 69907-67-1 /upload/more_svg/small/small_ET-075.svg
Formula C12H15NO4
MW 237.3
Purity >99%
Storage +2 ... +8 °C
Note Mal-AMCHC is used as a linker in various applications. It is employed as an antibody-drug linker in approved cancer medication Kadcyla by Genentech/Roche and used as a linker in PCA-062 by Novartis, currently in clinical trials. It is also used in IMMU-132 by Immunomedics, currently in clinical trials.
Code Name Synonym
ET-156 Mal(Br2)-AMCHC 3,4-dibromo-maleimido-AMCHC // 3,4-dibromo-maleimido tranexamic acid // trans‐4‐[(3,4‐dibromo‐2,5‐dioxo‐2,5‐dihydro‐1H‐ pyrrol‐1‐yl)methyl]cyclohexane‐1‐carboxylic acid
CAS n/a /upload/small/small_et-156.svg
Formula C12H13Br2NO4
MW 395
Purity >98%
Storage +2 ... +8 °C
Note Mal(Br2)-AMCHC is used as a bio-conjugation reagent for antibody-drug-conjugate synthesis. The di-bromo maleimide is a novel conjugation tool that addresses the retro-Michael instability of simple thiosuccinimide linkage. Chudasama V. et al. Drug Discovery Today: Tech. (2018), 30, 27-34. DOI:10.1016/j.ddtec.2018.07.002;  Bioconjugate Chem. (2011), 22(2), 132-136. DOI:10.1021/bc1004685; J. Am. Chem. Soc. (2012), 134(3), 1847-1852. DOI:10.1021/ja210335f; Bioconjugate Chem. (2018), 29(2), 486-492. DOI:10.1021/acs.bioconjchem.7b00795.
Code Name Synonym
ET-129 Mal(3-Me)-AMCHC 4-[(metylmaleimido)methyl]cyclohexane-1-carboxylic acid // (1r,4r)-4-[(3-methyl-2,5-dioxopyrrol-1- yl)methyl]cyclohexane-1-carboxylic acid
CAS 71738-82-4 /upload/more_svg/small/small_et-129.svg
Formula C13H17NO4
MW 251.3
Purity >99%
Storage +2 ... +8 °C
Note

Introduction of methyl group at maleimide core improves stability of maleimide-thiol conjugates.

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Code Name Synonym
ET-066 Mal-AMCHC-OSu SMCC // trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate // N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate
CAS 71875-81-5 /upload/more_svg/small/small_ET-066.svg
Formula C16H18N2O6
MW 334.3
Purity >99%
Storage +2 ... +8 °C

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