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Code Name Synonym
ET-129 Mal(3-Me)-AMCHC 4-[(metylmaleimido)methyl]cyclohexane-1-carboxylic acid // (1r,4r)-4-[(3-methyl-2,5-dioxopyrrol-1- yl)methyl]cyclohexane-1-carboxylic acid
CAS 71738-82-4 /upload/more_svg/small/small_et-129.svg
Formula C13H17NO4
MW 251.3
Purity >99%
Storage +2 ... +8 °C
Note

Introduction of methyl group at maleimide core improves stability of maleimide-thiol conjugates.

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Code Name Synonym
ET-066 Mal-AMCHC-OSu SMCC // trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate // N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate
CAS 71875-81-5 /upload/more_svg/small/small_ET-066.svg
Formula C16H18N2O6
MW 334.3
Purity >99%
Storage +2 ... +8 °C
Note Used as a linker for ADC construction. ACS Omega, 2019, 8834; DOI: 10.1021/acsomega.9b00430.
Code Name Synonym
ET-174 Mal-AMCHC-N-Propargylamide MCC-Yne // trans‐4‐[(2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐ yl)methyl]‐N‐(prop‐2‐yn‐1‐yl)cyclohexane‐1‐carboxamide // SMCC Propargyl amide // Maleimido-AMCHC-Propargylamide // Mal-AMCHC-N-Propynyl
CAS 2027476-42-0, 1036847-90-1 (cis,trans) /upload/small/small_et-174.svg
Formula C15H18N2O3
MW 274.3
Purity >98%
Storage +2 ... +8 °C
Note Used as a bio-conjugation reagent for antibody-drug-conjugate synthesis using Click-Chemistry. WO2019154120A1; US20160303253A1; US20170360770A1; Govindan, S. V. et. al. J. Med. Chem. 2008, 6916, DOI:10.1021/jm800719t.
Code Name Synonym
AA-150 H-Abu(3-N3).HCl (2S,3R) (2S,3R)-2-amino-3-azidobutanoic acid hydrochloride
CAS /upload/more_svg/small/small_AA-150.svg
Formula C4H9ClN4O2
MW 180.6
Purity >98%
Storage +2 ... +8 °C
Note H-Abu(3-N3) is incorporated into peptides and proteins that can be further selectively modified using Staudinger ligation or Click-chemistry.
Code Name Synonym
AA-149 H-Abu(3-N3).HCl (2S,3S) (2S,3S)-2-amino-3-azidobutanoic acid hydrochloride
CAS /upload/more_svg/small/small_AA-149.svg
Formula C4H9ClN4O2
MW 180.6
Purity >98%
Storage +2 ... +8 °C
Note H-Abu(3-N3) is incorporated into peptides and proteins that can be further selectively modified using Staudinger ligation or Click-chemistry.
Code Name Synonym
FM-261 Fmoc-Abu(3-NH2).HCl(2S,3S) 2-(Fmoc-amino)-3-amino butanoic acid // Fmoc-allo-azaThr // Fmoc-L-allo-azaThr-OH
CAS 244052-24-2, 788808-40-2 (net) /upload/small/small_fm-261.svg
Formula C19H21ClN2O4
MW 376.8
Purity >98%
Storage +2 ... +8 °C
Code Name Synonym
FM-181 Fmoc-Abu(3-N3) (2R,3R) (2R,3R)-(Fmoc-amino)-3-azidobutanoic acid
CAS 1229394-75-5 /upload/more_svg/small/small_FM-181.svg
Formula C19H18N4O4
MW 366.4
Purity >98%
Storage +2 ... +8 °C
Note Protected building-block for the synthesis of 2,3-diaminobutanoic acid containing peptides and also for "click" reactions. Eur. J. Org. Chem. (2010), (13), 2536-2543. DOI:10.1002/ejoc.200901345.
Code Name Synonym
FM-208 Fmoc-Abu(3-N3) (2R,3S) (2R,3S)-(Fmoc-amino)-3-azidobutanoic acid
CAS 1932349-21-7 /upload/more_svg/small/small_fm-208.svg
Formula C19H18N4O4
MW 366.4
Purity >98%
Storage +2 ... +8 °C
Code Name Synonym
FM-197 Fmoc-Abu(3-N3) (2S,3R) (2S,3R)-(Fmoc-amino)-3-azidobutanoic acid
CAS 146306-79-8 /upload/more_svg/small/small_FM-197.svg
Formula C19H18N4O4
MW 366.4
Purity >98%
Storage +2 ... +8 °C
Note Protected building-block for the synthesis of 2,3-diaminobutanoic acid containing peptides and also for "click" reactions. ChemMedChem (2017), 12(15), 1169-1172. DOI:10.1002/cmdc.201700300.
Code Name Synonym
FM-175 Fmoc-Abu(3-N3) (2S,3S) (2S,3S)-(Fmoc-amino)-3-azidobutanoic acid
CAS 131669-42-6 /upload/more_svg/small/small_FM-175.svg
Formula C19H18N4O4
MW 366.4
Purity >98%
Storage +2 ... +8 °C
Note Protected building-block for the synthesis of 2,3-diaminobutanoic acid containing peptides and also for "click" reactions. Journal of Natural Products (2017), 80(9), 2484-2491. DOI:10.1021/acs.jnatprod.7b00359; ChemMedChem (2017), 12(15), 1169-1172. DOI:10.1002/cmdc.201700300; Mendelsohn, Brian Alan PCT Int. Appl. (2015), WO 2015183978 A1.

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