| Code | Name | Synonym |
| ET-075 | Mal-AMCHC | 4-(maleimidomethyl)cyclohexane-1-carboxylic acid // trans-4-[(2,5-Dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]cyclohexanecarboxylic acid |
| CAS | 69907-67-1 |  |
| Formula | C12H15NO4 | |
| MW | 237.3 | |
| Purity | >99% | |
| Storage | +2 ... +8 °C | |
| Note | Mal-AMCHC is used as a linker in various applications. It is employed as an antibody-drug linker in approved cancer medication Kadcyla by Genentech/Roche and used as a linker in PCA-062 by Novartis, currently in clinical trials. It is also used in IMMU-132 by Immunomedics, currently in clinical trials. | |
| Code | Name | Synonym |
| ET-156 | Mal(Br2)-AMCHC | 3,4-dibromo-maleimido-AMCHC // 3,4-dibromo-maleimido tranexamic acid // trans‐4‐[(3,4‐dibromo‐2,5‐dioxo‐2,5‐dihydro‐1H‐ pyrrol‐1‐yl)methyl]cyclohexane‐1‐carboxylic acid |
| CAS | n/a |  |
| Formula | C12H13Br2NO4 | |
| MW | 395 | |
| Purity | >98% | |
| Storage | +2 ... +8 °C | |
| Note | Mal(Br2)-AMCHC is used as a bio-conjugation reagent for antibody-drug-conjugate synthesis. The di-bromo maleimide is a novel conjugation tool that addresses the retro-Michael instability of simple thiosuccinimide linkage. Chudasama V. et al. Drug Discovery Today: Tech. (2018), 30, 27-34. DOI:10.1016/j.ddtec.2018.07.002; Bioconjugate Chem. (2011), 22(2), 132-136. DOI:10.1021/bc1004685; J. Am. Chem. Soc. (2012), 134(3), 1847-1852. DOI:10.1021/ja210335f; Bioconjugate Chem. (2018), 29(2), 486-492. DOI:10.1021/acs.bioconjchem.7b00795. | |
| Code | Name | Synonym |
| ET-129 | Mal(3-Me)-AMCHC | 4-[(metylmaleimido)methyl]cyclohexane-1-carboxylic acid // (1r,4r)-4-[(3-methyl-2,5-dioxopyrrol-1- yl)methyl]cyclohexane-1-carboxylic acid |
| CAS | 71738-82-4 |  |
| Formula | C13H17NO4 | |
| MW | 251.3 | |
| Purity | >99% | |
| Storage | +2 ... +8 °C | |
| Note | Introduction of methyl group at maleimide core improves stability of maleimide-thiol conjugates. Access article |
|
| Code | Name | Synonym |
| ET-066 | Mal-AMCHC-OSu | SMCC // trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate // N-Succinimidyl 4-(Maleimidomethyl)cyclohexane-1-carboxylate |
| CAS | 71875-81-5, 64987-85-5 |  |
| Formula | C16H18N2O6 | |
| MW | 334.3 | |
| Purity | >99% | |
| Storage | +2 ... +8 °C | |
| Note | Used as a linker for ADC construction. ACS Omega, 2019, 8834; DOI: 10.1021/acsomega.9b00430. | |
| Code | Name | Synonym |
| ET-174 | Mal-AMCHC-N-Propargylamide | MCC-Yne // trans‐4‐[(2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐ yl)methyl]‐N‐(prop‐2‐yn‐1‐yl)cyclohexane‐1‐carboxamide // SMCC Propargyl amide // Maleimido-AMCHC-Propargylamide // Mal-AMCHC-N-Propynyl |
| CAS | 2027476-42-0, 1036847-90-1 (cis,trans) |  |
| Formula | C15H18N2O3 | |
| MW | 274.3 | |
| Purity | >98% | |
| Storage | +2 ... +8 °C | |
| Note | Used as a bio-conjugation reagent for antibody-drug-conjugate synthesis using Click-Chemistry. WO2019154120A1; US20160303253A1; US20170360770A1; Govindan, S. V. et. al. J. Med. Chem. 2008, 6916, DOI:10.1021/jm800719t. | |
| Code | Name | Synonym |
| AA-150 | H-Abu(3-N3).HCl (2S,3R) | (2S,3R)-2-amino-3-azidobutanoic acid hydrochloride |
| CAS |  |
|
| Formula | C4H9ClN4O2 | |
| MW | 180.6 | |
| Purity | >98% | |
| Storage | +2 ... +8 °C | |
| Note | H-Abu(3-N3) is incorporated into peptides and proteins that can be further selectively modified using Staudinger ligation or Click-chemistry. | |
| Code | Name | Synonym |
| AA-149 | H-Abu(3-N3).HCl (2S,3S) | (2S,3S)-2-amino-3-azidobutanoic acid hydrochloride |
| CAS |  |
|
| Formula | C4H9ClN4O2 | |
| MW | 180.6 | |
| Purity | >98% | |
| Storage | +2 ... +8 °C | |
| Note | H-Abu(3-N3) is incorporated into peptides and proteins that can be further selectively modified using Staudinger ligation or Click-chemistry. | |
| Code | Name | Synonym |
| FM-261 | Fmoc-Abu(3-NH2).HCl(2S,3S) | 2-(Fmoc-amino)-3-amino butanoic acid // Fmoc-allo-azaThr // Fmoc-L-allo-azaThr-OH |
| CAS | 244052-24-2, 788808-40-2 (net) |  |
| Formula | C19H21ClN2O4 | |
| MW | 376.8 | |
| Purity | >98% | |
| Storage | +2 ... +8 °C | |
| Code | Name | Synonym |
| FM-181 | Fmoc-Abu(3-N3) (2R,3R) | (2R,3R)-(Fmoc-amino)-3-azidobutanoic acid |
| CAS | 1229394-75-5 |  |
| Formula | C19H18N4O4 | |
| MW | 366.4 | |
| Purity | >98% | |
| Storage | +2 ... +8 °C | |
| Note | Protected building-block for the synthesis of 2,3-diaminobutanoic acid containing peptides and also for "click" reactions. Eur. J. Org. Chem. (2010), (13), 2536-2543. DOI:10.1002/ejoc.200901345. | |
| Code | Name | Synonym |
| FM-208 | Fmoc-Abu(3-N3) (2R,3S) | (2R,3S)-(Fmoc-amino)-3-azidobutanoic acid |
| CAS | 1932349-21-7 |  |
| Formula | C19H18N4O4 | |
| MW | 366.4 | |
| Purity | >98% | |
| Storage | +2 ... +8 °C |
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