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Code Name Synonym
FM-242 Fmoc-Abu(3-guanidino(Boc)2)(2S,3S) (2S,3S)‐3‐{[(E)‐{[(tert‐butoxy)carbonyl]amino}({[(tert‐ butoxy)carbonyl]imino})methyl]amino}‐2‐({[(9H‐fluoren‐9‐yl)methoxy]carbonyl}amino)butanoic acid
CAS n/a /upload/small/small_fm-242.svg
Formula C30H38N4O8
MW 582.7
Purity >98%
Storage +2 ... +8 °C
Note This material is a sterically hindered Agp (2-amino-3-guanidino propionic acid) analogue that is used as a building-block in solid-phase peptide synthesis.
Code Name Synonym
ET-093 Biotinyl-Aca biotinamidocaproate // 6-[biotinamido]hexanoate // 6-biotinylamino-hexanoic acid // N-(+)-biotinyl-6-aminohexanoic acid // N-biotinylcaproic Acid
CAS 72040-64-3 /upload/more_svg/small/small_ET-093.svg
Formula C16H27N3O4S
MW 357.5
Purity >98%
Storage +2 ... +8 °C
Code Name Synonym
ET-094 Biotinyl-Aca-OSu Biotin-6-aminohexanoic acid-N-hydroxysuccinimide ester // Biotinamidocaproate-N-hydroxysuccinimide ester // N-Succinimidyl N-biotinyl-6-aminocaproate // Succinimidyl 6-[biotinamido]hexanoate
CAS 72040-63-2 /upload/more_svg/small/small_ET-094.svg
Formula C20H30N4O6S
MW 454.5
Purity >98%
Storage +2 ... +8 °C
Note Biot-Aca-OSu is a biotinylation reagent containing aminocaproic acid linker that reacts with amines. Nature Medicine (2008), 14(8), 869-874.
DOI:10.1038/nm.1711; Nature Nanotech. (2010), 5(9), 660-665. DOI:10.1038/nnano.2010.148; Bioconjugate Chem. (2018), 29(2), 245-249. DOI:10.1021/acs.bioconjchem.7b00826; Chem.-Eur. J. (2018), 24(44), 11292-11296. DOI:10.1002/chem.201802365.
Code Name Synonym
ET-173 Fmoc-Aca-DIM Fmoc-Ddax-OH // (9H‐fluoren‐9‐yl)methyl N‐[6‐(4,4‐dimethyl‐2,6‐ dioxocyclohexylidene)‐6‐hydroxyhexyl]carbamate
CAS 2379561-08-5 /upload/small/small_et-173.svg
Formula C29H33NO5
MW 475.6
Purity >98%
Storage -15 ... -25 °C
Note Used as a next-generation traceless "helping hand" solubilizing tag in SPPS. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilising tag can be removed with 1M hydrazine or hydroxylamine solution. This linker is more stable than its predecessor Fmoc-Ddae-OH. Kay, M. S. et. al. ChemRxiv 2019, 1-12.
Code Name Synonym
FM-004 Fmoc-6-Aca 6-(Fmoc-amino)hexanoic acid // Fmoc-Ahx // Fmoc-Ahx-OH // Fmoc-Acp-OH
CAS 88574-06-5 /upload/more_svg/small/small_FM-004.svg
Formula C21H23NO4
MW 353.4
Purity >99%
Storage +2 ... +8 °C
Note Fmoc-Aca is used as a linker in various applications. DOI:10.1021/bc200279b; Science (2010), 330(6011), 1689-1692. DOI:10.1126/science.1196154; ACIEE (2014), 53(4), 1012-1016. DOI:10.1002/anie.201308834; Chem. Comm. (2018), 54(4), 401-404. DOI:10.1039/C7CC08127H; ACS Central Science (2018), 4(5), 582-589.  DOI:10.1021/acscentsci.8b00060.
Specification Link
Code Name Synonym
ET-159 Mal(Br2)-Aca 6‐(3,4‐dibromo‐2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)hexanoic acid // 3,4-dibrommaleimido-aminohexanoic acid // dibrommaleimido aminocaproic acid // DB-Aca // DBM-Aca
CAS 1443214-97-8 /upload/small/small_et-159.svg
Formula C10H11Br2NO4
MW 369
Purity >98%
Storage +2 ... +8 °C
Note Mal(Br2)-Aca is used as a bio-conjugation reagent for antibody-drug-conjugate synthesis. The di-bromo maleimide is a novel conjugation tool that addresses the retro-Michael instability of simple thiosuccinimide linkage. Baker et al Organic & Biomolecular Chemistry (2014), 12(37), 7261-7269. DOI:10.1039/C4OB01550A; Jackson et al Molecular Pharmaceutics (2015), 12(11), 3986-3998. DOI:10.1021/acs.molpharmaceut.5b00432; Baker et al Organic & Biomolecular Chemistry (2017), 15(14), 2947-2952. DOI:10.1039/C7OB00220C.
Code Name Synonym
ET-160 Mal(Br2)-Aca-OSu 2,5‐dioxopyrrolidin‐1‐yl 6‐(3,4‐dibromo‐2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)hexanoate // 3,4-dibrommaleimido-aminohexanoic acid NHS ester // dibrommaleimido aminocaproic acid NHS ester // DB-Aca-OSu // DBM-Aca-OSu // DB-Aca-NHS // DBM-Aca-NHS
CAS 2389064-41-7 /upload/small/small_et-160.svg
Formula C14H14Br2N2O6
MW 466.1
Purity >97%
Storage +2 ... +8 °C
Note Mal(Br2)-Aca-OSu is used as a bio-conjugation reagent for antibody-drug-conjugate synthesis. The di-bromo maleimide is a novel conjugation tool that addresses the retro-Michael instability of simple thiosuccinimide linkage. Baker et al Organic & Biomolecular Chemistry (2014), 12(37), 7261-7269. DOI:10.1039/C4OB01550A; Jackson et al Molecular Pharmaceutics (2015), 12(11), 3986-3998. DOI:10.1021/acs.molpharmaceut.5b00432; Baker et al Organic & Biomolecular Chemistry (2017), 15(14), 2947-2952. DOI:10.1039/C7OB00220C.
Code Name Synonym
ET-152 N3-Aca-OSu 2,5-dioxopyrrolidin-1-yl 6-azidohexanoate
CAS 866363-70-4 /upload/small/small_ET-152.svg
Formula C10H14N4O4
MW 254.2
Purity >98%
Storage -15 ... -25 °C
Note N3-Aca-OSu is used as a linker that can be further modified at the azido-position using Staudinger ligation or Click-chemistry. J. Org. Chem. (2005), 70(18), 7123-7132. DOI:10.1021/jo0505472; J. Am. Chem. Soc. (2008), 130(4), 1328-1334. DOI:10.1021/ja075937f; Chem. Comm. (2011), 47(22), 6257-6259. DOI:10.1039/c1cc10743g;  J. Am. Chem. Soc. (2018), 140(13), 4712-4720. DOI:10.1021/jacs.8b01462; Angew. Chem. Int. Ed. (2018), 57(32), 10257-10262. DOI:10.1002/anie.201806710.
Code Name Synonym
FM-006 Fmoc-ACBC 1-(Fmoc-amino)cyclobutyl-1-carboxylic acid
CAS 885951-77-9 /upload/more_svg/small/small_FM-006.svg
Formula C20H19NO4
MW 337.4
Purity >99%
Storage +2 ... +8 °C
Note Fmoc-ACBC is used in the synthesis of modified peptides and peptidomimetics. JACS (2013), 135(2), 669-682. DOI:10.1021/ja306028q; DOI:10.1021/jm3015298;  J. Med. Chem. (2018), 61(9), 4263-4269. DOI:10.1021/acs.jmedchem.8b00488.
Specification Link
Code Name Synonym
BO-004 Boc-ACPA 1-(Boc-aminomethyl)cyclopropyl-1-carboxylic acid
CAS 204376-48-7 /upload/more_svg/small/small_BO-004.svg
Formula C10H17NO4
MW 215.2
Purity >99%
Storage +2 ... +8 °C
Specification Link

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