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Code Name Synonym
DI-122 1-(Boc-amino)-3-oxa-5-pentaneamine 9 - N-Boc-2-(2-amino-ethoxy)-ethylamine // N-(tert-Butoxycarbonyl)-2-(2-aminoethoxy)ethylamine // tert-Butyl [2-(2-Aminoethoxy)ethyl]carbamate // [2-(2-Aminoethoxy)ethyl]carbamic Acid tert-Butyl Ester
CAS 127828-22-2 /upload/small/small_DI-122.svg
Formula C9H20N2O3
MW 204.3
Purity >98%
Storage +2 ... +8 °C
Code Name Synonym
ET-161 Biotinyl-TOTA N-(13-amino-4,7,10-trioxatridecanyl)-D-biotinamide // Biotin-TOTA // 5‐[(3aS,4S,6aR)‐2‐oxo‐hexahydro‐1H‐thieno[3,4‐ d]imidazol‐4‐yl]‐N‐(3‐{2‐[2‐(3‐ aminopropoxy)ethoxy]ethoxy}propyl)pentanamide
CAS 183896-00-6 /upload/small/small_et-161.svg
Formula C20H38N4O5S
MW 446.6
Purity >98%
Storage +2 ... +8 °C
Note This reagent is a water-soluble biotinylation reagent that can be coupled to carboxylic acids and various electrophiles. Hang et al J. Am. Chem. Soc. (2009), 131(13), 4967-4975. DOI:10.1021/ja810122f; Tinberg, C. E.; Khare, S. D.; Dou, J.; Doyle, L.; Nelson, J. W.; Schena, A.; Jankowski, W.; Kalodimos, C. G.; Johnsson, K.; Stoddard, B. L.; et al Nature  (2013), 501(7466), 212-216. DOI:10.1038/nature12443; Shajahan, A.; Parashar, S.; Goswami, S.; Ahmed, S. M.; Nagarajan, P.; Sampathkumar, S.-G. J. Am. Chem. Soc. (2017), 139(2), 693-700. DOI:10.1021/jacs.6b08894.
Code Name Synonym
ET-086 Biotinyl-TOTA-glutaramic acid DIPEA salt
CAS 1205744-09-7, 1202761-21-4 net /upload/more_svg/small/small_ET-086.svg
Formula C33H63N5O8S
MW 689.9
Purity >98%
Storage -15 ... -25 °C
Code Name Synonym
DI-005 Boc-1-amino-4,7,10-trioxa-13-tridecanamine tert-butyl N-(3-{2-[2-(3- aminopropoxy)ethoxy]ethoxy}propyl)carbamate // Boc-TOTA
CAS 194920-62-2 /upload/more_svg/small/small_DI-005.svg
Formula C15H32N2O5
MW 320.4
Purity >98%
Storage +2 ... +8 °C
Note Boc-TOTA is used as a linker in various applications. J. Am. Chem. Soc. (2008), 130(34), 11467-11476. DOI:10.1021/ja803036e; Science (2015), 348(6241), 1376-1381. DOI:10.1126/science.aab1433; Journal of Biological Chemistry (2018), 293(21), 8285-8294.DOI:10.1074/jbc.RA118.002316.
Specification Link
Code Name Synonym
DI-008 Fmoc-1-amino-4,7,10-trioxa-13-tridecanamine.HCl Fmoc-TOTA.HCl // 1-(9-Fluorenylmethyloxycarbonyl-amino)-4,7,10-trioxa-13-tridecanamine.HCl
CAS 868599-75-1 , 308241-31-8 net /upload/more_svg/small/small_DI-008.svg
Formula C25H35ClN2O5
MW 479
Purity >99%
Storage -15 ... -25 °C
Note Fmoc-TOTA is used as a linker in various applications. DOI:10.1021/jm050234z; PCT Int. Appl. (2016), WO 2016077518 A1.
Specification Link
Code Name Synonym
DI-126 1-Z-4,7,10-trioxa-13-tridecaneamine Z-TOTA // Cbz-TOTA // benzyl N‐(3‐{2‐[2‐(3-aminopropoxy)ethoxy]ethoxy}propyl)carbamate
CAS 220156-99-0 /upload/small/small_di-126.svg
Formula C18H30N2O5
MW 354.4
Purity >98%
Storage +2 ... +8 °C
Note Z-TOTA is used as a PEG-containing di-amine building-block in the synthesis of various hydrophilic linkers. Harris T. D. et. al. Bioconj. Chem. 2006, 1294, DOI:10.1021/bc060063s; Spiegel D. A. et.al. ACS Chem. Biol. 2013, 2404, DOI:10.1021/cb4004942; Brönstrup M. et. al. Angew. Chem. Int. Ed. 2017, 8272, DOI:10.1002/anie.201701358; Wu Y.-W., Waldmann H. et. al. Nature Chem. Biol. 2019, 710, DOI:10.1038/s41589-019-0307-5.
Code Name Synonym
DI-006 Boc-1-amino-4,9-dioxa-12-dodecanamine tert-butyl N-{3-[4-(3- aminopropoxy)butoxy]propyl}carbamate
CAS 275823-77-3 /upload/more_svg/small/small_DI-006.svg
Formula C15H32N2O4
MW 304.4
Purity >98%
Assay C15H32N2O4
Storage +2 ... +8 °C
Specification Link
Code Name Synonym
DI-010 Fmoc-1-amino-4,9-dioxa-12-dodecanamine.HCl 9H-fluoren-9-ylmethyl N-{3-[4-(3- ammoniopropoxy)butoxy]propyl}carbamate chloride // Fmoc-DODA.HCl
CAS 1274891-99-4, 1263044-43-4 net /upload/more_svg/small/small_DI-010.svg
Formula C25H35ClN2O4
MW 463
Purity >99%
Storage -15 ... -25 °C
Specification Link
Code Name Synonym
DI-051 Fmoc-PIP.HCl 9H-fluoren-9-ylmethyl piperazine-1-carboxylate hydrochloride // Fmoc-paz hydrochloride // Fmoc-paz HCl // Fmoc-piperazine hydrochloride
CAS 215190-22-0 , 219312-89-7 net /upload/more_svg/small/small_DI-051.svg
Formula C19H21ClN2O2
MW 344.8
Purity >99%
Storage -15 ... -25 °C
Code Name Synonym
ET-167 N3-C11H22-COOH 12-Azidododecanoic acid // 12-ADA // 12AZ // 12-Azido-dodecanoic acid
CAS 80667-36-3 /upload/small/small_et-167.svg
Formula C12H23N3O2
MW 241.3
Purity >98%
Storage +2 ... +8 °C
Note Used as a hydrophobic bioconjugation linker (using N-Myristoyltransferase) that can be further modified at the azido-position using Staudinger ligation or Click-chemistry. Kinzer-Ursem, T. L. Bioconjugation, 2019, 149, DOI:10.1007/978-1-4939-9654-4_11; Tirrell, D. A. J. Am. Chem. Soc. 2016, 15098, DOI:10.1021/jacs.6b07067.

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