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Code Name Synonym
SU-063 Z-Phe-Arg-AMC.HCl Z-FR-AMC // Z-Phe-Arg-7-amido-4-methylcoumarin hydrochloride // N-CBZ-Phe-Arg-AMC
CAS 65147-22-0 /upload/small/small_su-063.svg
Formula C33H37ClN6O6
MW 649.2
Purity >98%
Storage +2 ... +8 °C
Note Z-Phe-Arg-AMC is a fluorogenic substrate for various serine proteases like cathepsins, kallikrein and plasmin. Substrate of papain, cruzain and trypsin. Absorption/emission of substrate = 330/390 nm (weak fluorescence) Absorption/emission of end product (AMC) = 342/441 nm (strong fluorescence). Levy M. A. et. al. J. Biol. Chem. 1996, 12517, DOI:10.1074/jbc.271.21.12517; Niles A. L. et. al. Anal. Biochem. 2007, 197, DOI:10.1016/j.ab.2007.04.007; Huck W. T. S. et. al. Angew. Chem. Int. Ed. 2018, 14065, DOI:10.1002/anie.201806944.

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