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Code Name Synonym
AA-147 H-Phe(4-N3).HCl 4-Azido-L-phenylalanine hydrochloride // 3-(p-Azidophenyl)-L-alanine Hydrochloride // 4-Azidophenylalanine Hydrochloride // p-Azido-L-phenylalanine Hydrochloride // p-Azidophenylalanine Hydrochloride // H-4-Azido-Phe.HCl // Phe(pN3).HCl // para-azido-Phe.HCl
CAS 34670-43-4 , 33173-53-4 net /upload/small/small_aa-147.svg
Formula C9H11ClN4O2
MW 242.7
Purity >98%
Storage -15 ... -25°C
Note H-Phe(4-N3) is used in protein biosynthesis as unnatural amino acid for genetic code expansion. The azido-funcionality can be further utilized to cross-link various functionalities to proteins utilizing click-chemistry. DOI:10.1126/science.1084772; DOI:10.1038/nature08817; DOI:10.1038/nature14095;
The azido-functionality is IR-active and can be used in protein active site electrostatic environment studies. DOI:10.1038/nchembio.167;
The azide-handle can also be used for protein PEGylation or attachment to antibodies using click-chemistry. DOI:10.1021/acssynbio.7b00316; U.S. (2

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