Fmoc-Lys(Poc)

Synonyms
Fmoc-L-Lys(Poc) // Fmoc-Lys(Proc) // N-alpha-(9-fluorenylmethyloxycarbonyl)-N-epsilon-(prop-2-ynyloxycarbonyl)-L-lysine // (2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6- {[(prop-2-yn-1-yloxy)carbonyl]amino}hexanoic acid

ID

FM-216

Formula

C25H26N2O6

CAS

1584133-25-4

MW

450.5

Purity

>98% (HPLC)

Storage

+2 ... +8 °C

Product image

References

Used to incorporate Poc-protected Lysine into peptides and proteins. The Poc-group can be selectively cleaved in bio-environment using biocompatible Pd-catalysis releasing free Lysine residue and activating the protein. Poc-group can also be modified using click-chemistry. Nature Chem. (2014), 6(4), 352-361. DOI:10.1038/nchem.1887; Org. Lett. (2018), 20(23), 7493-7497. DOI:10.1021/acs.orglett.8b03261.

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