Fmoc-AEEP-DIM

Synonyms
Fmoc-Ddae-OH // (9H‐fluoren‐9‐yl)methyl N‐(2‐{2‐[3‐(4,4‐dimethyl‐ 2,6‐dioxocyclohexylidene)‐3‐ hydroxypropoxy]ethoxy}ethyl)carbamate

ID

ET-171

Formula

C30H35NO7

CAS

1988771-96-5

MW

521.6

Purity

>98%

Storage

-15 ... -25 °C

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References

Fmoc-Ddae-OH is used as a solubility-enhancing linker in the “helping hand” strategy for purification of highly insoluble peptides. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilising tag can be removed with 1M hydrazine or hydroxylamine solution. Kay, M. S.; Aucagne, V. J. Am. Chem. Soc. 2016, 11775. DOI: 10.1021/jacs.6b05719; Chou, D. H-C. Org. Biomol. Chem. 2019, 1703. DOI: 10.1039/c8ob01212a.

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