Fmoc-D-Thz(Me2)

Synonyms
Fmoc-D-Thz(2-Me2) // Fmoc-(4-S)-2,2-dimethyl-1,3-thiazolidine-4-carboxylic acid // Fmoc-D-Dtc // Fmoc-D-Dtc-OH // Fmoc-D-Cys(ψMe,MePro)-OH // Fmoc-D-Cys(ψMe,MePro) // Fmoc-D-Cysteine Pseudoproline

ID

FM-118

Formula

C21H21NO4S

CAS

1932198-36-1

MW

383.5

Purity

>99%

Storage

+2 to +8 °C

Product image

References

Used in SPPS as a Cys pseudoproline that helps to disrupt the secondary structure and increase the solubilization of protected peptides. Can be cleaved using TFA/TIS/H2O (95:2.5:2.5) for several hours at rt.

Postma, T. M.; Albericio, F. Org. Lett. 2014, 1772;

https://doi.org/10.1021/ol5004725

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