Fmoc-MeDbz

References

Fmoc-MeDbz is used as a linker in peptide synthesis. It can be cyclysed into a N-acyl-N-methylacylurea using Nitrophenyl chloroformate.

J. Am. Chem.Soc. 2015, 137(22), 7197-7209;

https://doi.org/10.1021/jacs.5b03504

J. Am. Chem.Soc. 2016, 138(15), 5069-5075;

https://doi.org/10.1021/jacs.5b13580

J. Am. Chem.Soc. 2016, 138(41), 13461-13464;

https://doi.org/10.1021/jacs.6b05389

Tetrahedron. Lett. 2018, 59(18), 1779-1782;

https://doi.org/10.1016/j.tetlet.2018.03.084

Angew. Chem. Int. Ed. 2018, 57(8), 2105-2109;

https://doi.org/10.1002/anie.201711546

Brik, A. et. al. Angew. Chem. Int. Ed. 2021, 60(13), 7333-7343;

https://doi.org/10.1002/anie.202016208

Modified capping procedure:

https://doi.org/10.1016/j.tetlet.2018.08.061