Fmoc-Lys(Mtt-Aoa)

Synonyms
(2S)-2-{[(9H-fluoren-9-ylmethoxy)carbonyl]amino}-6-[2-({[(4- methylphenyl)diphenylmethyl]amino}oxy)acetamido]hexanoic acid

ID

FM-226

Formula

C43H43N3O6

CAS

2250436-45-2

MW

697.8

Purity

>97%

Storage

+2 ... +8 °C

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References

Overacylation at aminooxy acetic acid (Aoa) is a well known and described problem. Amide functionality at Aoa and/or hindered protecting groups such as trityl prevent overacylation. 
We offer an advanced Aoa building block resistant to overacylation, combining both - amide linkage (to Lys side chain) and a hindered protecting group (Mtt).
Decostaire, I.P.; Lelie`vre, D.; Zhang, H.; Delmas, A.F. Tetrahedron Letters 200647, 7057–7060.

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