H-Phe(4-N3).HCl

ID	AA-147
Formula	C₉H₁₁ClN₄O₂
CAS	34670-43-4, 33173-53-4 net
MW	242.7
Purity	>98%
Isomeric purity	>99.9%
Storage	-15 to -25 °C

References

H-Phe(4-N3) is used in protein biosynthesis as unnatural amino acid for genetic code expansion. The azido-funcionality can be further utilized to cross-link various functionalities to proteins utilizing click-chemistry.

https://doi.org/10.1126/science.1084772

https://doi.org/10.1038/nature08817

https://doi.org/10.1038/nature14095

https://doi.org/10.1021/acscentsci.1c00499

The azido-functionality is IR-active and can be used in protein active site electrostatic environment studies.

https://doi.org/10.1038/nchembio.167

Angew. Chem. Int. Ed. 2022, 61, e202200648;

https://doi.org/10.1002/anie.202200648

The azide-handle can also be used for protein PEGylation or attachment to antibodies using click-chemistry.

https://doi.org/10.1021/acssynbio.7b00316

Methods, 2023, 219, 95-101

https://doi.org/10.1016/j.ymeth.2023.10.001