Mal(Br2)-Aca

Synonyms
6‐(3,4‐dibromo‐2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)hexanoic acid // 3,4-dibrommaleimido-aminohexanoic acid // dibrommaleimido aminocaproic acid // DB-Aca // DBM-Aca

ID

ET-159

Formula

C10H11Br2NO4

CAS

1443214-97-8

MW

369

Purity

>98%

Storage

+2 to +8 °C

Product image

References

Mal(Br2)-Aca is used as a bio-conjugation reagent for antibody-drug-conjugate synthesis. The di-bromo maleimide is a novel conjugation tool that addresses the retro-Michael instability of simple thiosuccinimide linkage.

Org. Biomol. Chem. 2014, 12(37), 7261-7269;

https://doi.org/10.1039/C4OB01550A

Mol. Pharmaceutics 2015, 12(11), 3986-3998;

https://doi.org/10.1021/acs.molpharmaceut.5b00432

Org. Biomol. Chem. 2017, 15(14), 2947-2952;

https://doi.org/10.1039/C7OB00220C

Bioconjugate Chem. 2021, 32, 1214−1222;

https://doi.org/10.1021/acs.bioconjchem.0c00710

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