Mal(Br2)-Aca-OSu

References

Mal(Br2)-Aca-OSu is used as a bio-conjugation reagent for antibody-drug-conjugate synthesis. The di-bromo maleimide is a novel conjugation tool that addresses the retro-Michael instability of simple thiosuccinimide linkage.

Baker et al Organic & Biomolecular Chemistry (2014), 12(37), 7261-7269

DOI:10.1039/C4OB01550A

Jackson et al Molecular Pharmaceutics (2015), 12(11), 3986-3998

DOI:10.1021/acs.molpharmaceut.5b00432

Baker et al Organic & Biomolecular Chemistry (2017), 15(14), 2947-2952

DOI:10.1039/C7OB00220C