Mal(Br2)-AEEA

Synonyms
3,4-dibrommaleimido-AEEA // dibrommaleimido AEEA // DB-AEEA // DBM-AEEA // 3,4-dibrommaleimido 8-amino-3,6-dioxaoctanoic acid // 3,4-dibrommaleimido O2Oc // 3,4-dibrommaleimido Ado // 3,4-dibrommaleimido Adoa // 2‐{2‐[2‐(3,4‐dibromo‐2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)ethoxy]ethoxy}acetic acid

ID

ET-162

Formula

C10H11Br2NO6

CAS

n/a

MW

401

Purity

>98%

Storage

+2 ... +8 °C

Product image

References

Mal(Br2)-AEEA is used as a hydrophylic bio-conjugation reagent for antibody-drug-conjugate synthesis. The di-bromo maleimide is a novel conjugation tool that addresses the retro-Michael instability of simple thiosuccinimide linkage. Baker et al Organic & Biomolecular Chemistry (2014), 12(37), 7261-7269. DOI:10.1039/C4OB01550A; Jackson et al Molecular Pharmaceutics (2015), 12(11), 3986-3998. DOI:10.1021/acs.molpharmaceut.5b00432; Baker et al Organic & Biomolecular Chemistry (2017), 15(14), 2947-2952. DOI:10.1039/C7OB00220C.

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