Fmoc-D-Agb.HCl

Synonyms
[amino({[(3R)‐3‐carboxy‐3‐({[(9H‐fluoren‐9‐ yl)methoxy]carbonyl}amino)propyl]amino})methylidene]azanium chloride // 2-(Fmoc-amino)-4-guanidino-D-butyric acid // Fmoc-D-Agb-OH // Fmoc-D-Nar // Fmoc-D-norArg

ID

DD-200

Formula

C20H23ClN4O4

CAS

n/a

MW

418.9

Purity

>98%

Storage

+2 ... +8 °C

Product image

References

Used as a protected Arginine homologue in peptide synthesis. The guanidino-group is protected by protonation, which can be restored after Fmoc-cleavage by pre-washing of the peptide with Py.HBr (0.08M in DMF) for 10min. prior to the next coupling.  Asami, T. et al Bioorg. Med. Chem. Lett. (2012), 22(20), 6328-6332, DOI:10.1016/j.bmcl.2012.08.087; Heinis,C. et al J. Med. Chem. (2017), 60(3), 1151-1158, DOI:10.1021/acs.jmedchem.6b01548; Leprince, J. et al J. Med. Chem. (2018), 61(22), 10185-10197, DOI:10.1021/acs.jmedchem.8b01332.

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