Fmoc-Lys(Pentynoyl-DIM)

Synonyms
(2S)‐6‐{[1‐(4,4‐dimethyl‐2,6‐ dioxocyclohexylidene)pent‐4‐yn‐1‐yl]amino}‐2‐ ({[(9H‐fluoren‐9‐ yl)methoxy]carbonyl}amino)hexanoic acid

ID

FM-254

Formula

C34H38N2O6

CAS

2408993-33-7

MW

570.7

Purity

>98%

Storage

-15 ... -25 °C

Product image

References

Used as a SPPS bulding-block for the “helping hand” strategy for purification of highly insoluble peptides. Solubilising residues are attached to the Lys side-chains using Click-chemistry. The solubilising tag can be removed with 1M hydrazine or hydroxylamine solution. Kay, M.S.; Aucagne, V. J. Am. Chem. Soc. 2016, 11775. DOI: 10.1021/jacs.6b05719; Chou, D. H-C. Org. Biomol. Chem. 2019, 1703. DOI: 10.1039/c8ob01212a.

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