Fmoc-AEEP-DMB

Synonyms
(9H‐fluoren‐9‐yl)methyl N‐(2‐{2‐[3‐(1,3‐dimethyl‐2,4,6‐trioxo‐1,3‐diazinan‐5‐ylidene)‐3‐hydroxypropoxy]ethoxy}ethyl)carbamate

ID

ET-170

Formula

C28H31N3O8

CAS

n/a

MW

537.6

Purity

>98%

Storage

+2 to +8 °C

Product image

References

Fmoc-AEEP-DMB is used as a solubility-enhancing linker in the “helping hand” strategy for purification of highly insoluble peptides. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilising tag can be removed with 1M hydrazine or hydroxylamine solution.

Kay, M. S.; Aucagne, V. J. Am. Chem. Soc. 2016, 11775. DOI: 10.1021/jacs.6b05719;

Chou, D. H-C. Org. Biomol. Chem. 2019, 1703. DOI: 10.1039/c8ob01212a.

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