Z-Phe-Arg-AMC.HCl

Synonyms
Z-FR-AMC // Z-Phe-Arg-7-amido-4-methylcoumarin hydrochloride // N-CBZ-Phe-Arg-AMC

ID

SU-063

Formula

C33H37ClN6O6

CAS

65147-22-0

MW

649.2

Purity

>98%

Storage

+2 to +8 °C

Product image

References

Z-Phe-Arg-AMC is a fluorogenic substrate for various serine proteases like cathepsins, kallikrein and plasmin. Substrate of papain, cruzain and trypsin. Absorption/emission of substrate = 330/390 nm (weak fluorescence) Absorption/emission of end product (AMC) = 342/441 nm (strong fluorescence). Levy M. A. et. al. J. Biol. Chem. 1996, 12517, DOI:10.1074/jbc.271.21.12517; Niles A. L. et. al. Anal. Biochem. 2007, 197, DOI:10.1016/j.ab.2007.04.007; Huck W. T. S. et. al. Angew. Chem. Int. Ed. 2018, 14065, DOI:10.1002/anie.201806944.

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