Fmoc-Aeg(Dde)

References

Building block for preparation of protected PNA (Peptide Nucleic Acid) monomers.

For selective Dde-cleavage please refer to this information: The best results in terms of reactivity and selectivity were achieved using a mixture of NH₂OH*HCl/imidazole in NMP/CH₂Cl₂. After 3 h, the Dde group was cleaved cleanly while the Fmoc group was completely stable, yielding Dde-deprotected material as the only material with a quantitative yield.

Bradley, M. et. al. Org. Lett., 2004, 1127.

https://doi.org/10.1021/ol049905y