Fmoc-Sec(Mob)

ID	FM-269
Formula	C₂₆H₂₅NO₅Se
CAS	150308-80-8
MW	510.46
Purity	>99%
Isomeric purity	>99.9%
Storage	+2 to +8 °C

References

Building block for the introduction of selenocysteine by SPPS.

Peptides containing selenocysteine can be cleaved from the resin with simultaneous side-chain deprotection by treatment with 5% (v/v) water, 95% (v/v) trifluoroacetic acid
(TFA), 0.4 M 2,2’-dithiobis(5-nitropyridine) (DTNP) for 7 min at 60 °C or 2 h at RT.

Nature Chem. 2019, 78.

https://doi.org/10.1038/s41557-018-0154-0

Chem. Commun., 2020, 14239.

https://doi.org/10.1039/D0CC06252A

Chem.-Eur. J. 2020, 4695.

https://doi.org/10.1002/chem.202000309

Angew. Chem. Int. Ed. 2019, 14610.

https://doi.org/10.1002/anie.201909484

Angew. Chem. Int. Ed. 2023, 62, e202313037

https://doi.org/10.1002/anie.202313037

ChemBioChem. 2024, 25, e202300818

https://doi.org/10.1002/cbic.202300818