Boc-Sec(Mob)

References

Building block for the introduction of selenocysteine by SPPS in the terminal position.

Peptides containing selenocysteine can be cleaved from the resin with simultaneous side-chain deprotection by treatment with 5% (v/v) water, 95% (v/v) trifluoroacetic acid (TFA), 0.4 M 2,2’-dithiobis(5-nitropyridine) (DTNP) for 7 min at 60 °C or 2 h at RT.

Org. Biomol. Chem., 2011, 9, 1356.

https://doi.org/10.1039/C0OB00823K

PNAS, 2019, 13873-13878.

https://doi.org/10.1073/pnas.1905177116

For coupling conditions optimisation see:

Chem.-Eur. J., 2019, 10197-10203.

https://doi.org/10.1002/chem.201901778