Boc-Sec(Mob)-OPfp

References

Building block for the introduction of selenocysteine by SPPS in the terminal position.

Due to difficult coupling of Boc-Sec(Mob), this is an alternative building block for introduction of Sec residue into peptides. For use see:

ChemBioChem., 2008, 9, 1623 – 1631.

https://doi.org/10.1002/cbic.200700745

Peptides containing selenocysteine can be cleaved from the resin with simultaneous side-chain deprotection by treatment with 5% (v/v) water, 95% (v/v) trifluoroacetic acid (TFA), 0.4 M 2,2’-dithiobis(5-nitropyridine) (DTNP) for 7 min at 60 °C or 2 h at RT.