Boc-Ser(Psi(Me,Me)pro)-OH

References

Pseudoproline monomer for peptide synthesis. This building-block can be successfully coupled with many amino-acids using modern coupling techniques avoiding the need for pseudoproline dipeptides and giving the possibility to introduce pseudoprolines in peptides containing non-natural or rare amino-acids. For coupling efficiency studies of the corresponding Fmoc-derivative please refer to:

Senko, D. A. et. al. Amino Acids, 2021, 665;

https://doi.org/10.1007/s00726-021-02973-1

Asymmetric building-block for various applications, including Gerner's aldehyde synthesis.

J. Am. Chem. Soc. 2014, 136, 39, 13534–13537;

https://doi.org/10.1021/ja507295u

J. Am. Chem. Soc. 2019, 141, 14, 5788–5797;

https://doi.org/10.1021/jacs.8b13157