Boc-Thr(Psi(Me,Me)pro)-OH

References

Pseudoproline monomer for peptide synthesis. This building-block can be successfully coupled with many amino-acids using modern coupling techniques avoiding the need for pseudoproline dipeptides and giving the possibility to introduce pseudoprolines in peptides containing non-natural or rare amino-acids. For coupling efficiency studies of the corresponding Fmoc-derivative please refer to:

Senko, D. A. et. al. Amino Acids, 2021, 665;

https://doi.org/10.1007/s00726-021-02973-1

Asymmetric building-block for various applications.

J. Am. Chem. Soc. 2005, 127, 31, 11159–11175;

https://doi.org/10.1021/ja0529337

Angew. Chem. Int. Ed. 2020, 59, 11, 4375-4379;

https://doi.org/10.1002/anie.201916340