Fmoc-Lys(COCF2N3)

Synonyms
Fmoc-L-Lys(COCF2N3)-OH // (2S)‐2‐Fmoc-amino‐6‐(2‐azido‐2,2‐difluoroacetamido)hexanoic acid // Fmoc-Azidodifluoroacetil lysine

ID

FM-283

Formula

C23H23F2N5O5

CAS

n/a

MW

487.5

Purity

>98%

Isomeric purity

>99.7%

Storage

+2 to +8 °C

Product image

References

Building-block for incorporation of this NCAA into peptides for better click-conjugation. This difluoro-analogue shows a >2-fold increase in reactivity towards copper-free conjugation with BCN in comparison with the azido-acetyl analogue.

Bioconjugate Chem., 2015, 26, 11, 2233–2242;

https://doi.org/10.1021/acs.bioconjchem.5b00224

Chem. Commun., 2017, 53, 5024-5027;

https://doi.org/10.1039/C7CC01298E

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