Fmoc-D-Lys(MeDmb)

References

Novel Lysine building-block for SPPS bearing a new side-chain protecting-group. MeDmb is an orthogonal protecting group, stable under acidic and basic conditions used during SPPS and can be cleaved by a mild solution of 2% hydrazine hydrate in DMF and 2% hydroxylamine in DMF. The advantage of MeDmb over dimedone derivatives is the increased hydrophilicity, which should increase their solubility in a broad range of solvents, including green solvents.

ChemistrySelect 2021, 6, 6626 –6630;

https://doi.org/10.1002/slct.202101539