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Mal-Dap(Boc)-OSu

Synonyms
N-alpha-Maleimido-N-beta-Boc-L-2,3-diaminopropionic acid NHS ester // Mal-Dpr(Boc)-OSu // (S)-maleoyl-DPR(boc)-OSu // 2,5‐dioxopyrrolidin‐1‐yl (2S)‐3‐{[(tert‐butoxy)carbonyl]amino}‐2‐(2,5‐dioxo‐2,5‐dihydro‐1H‐pyrrol‐1‐yl)propanoate // Mal-L-Dap(Boc)-OSu

ID	ET-190
Formula	C₁₆H₁₉N₃O₈
CAS	1703778-79-3
MW	381.3
Purity	>98%
Isomeric purity	>99.7%
Storage	-15 to -25 °C

References

Mal-Dap(Boc)-OSu is used in drug conjugate construction leading to more stable conjugates due to Dap neighbouring-group assistance. This strategy is widely used by Seagen Inc. and others.

PCT Int. Appl. (2015), WO 2015057699 A2

PCT Int. Appl. (2017), WO 2017196598 A1

PCT Int. Appl. (2020), WO2020132655 A1

PCT Int. Appl. (2021), WO2021207701 A1

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