Boc-Sez

Synonyms
Boc-Sez-OH // (4R)‐3‐[(tert‐butoxy)carbonyl]‐1,3‐selenazolidine‐4‐carboxylic acid // Boc selenazolidine carboxylic acid // Boc-L-Sez-OH

ID

BO-167

Formula

C9H15NO4Se

CAS

1841180-44-6

MW

280.2

Purity

>98%

Isomeric purity

>99.9%

Storage

+2 to +8 °C

Product image

References

This selenocysteine-derived building-block is used in NCL/deselenization technique. NCL is performed at selenocysteine followed by a selective deselenization reaction,
which converts the Sec at the ligation site into Ala in the presence of unprotected Cys residues.

Sez is deprotected into Sec by treatment with MeONH2 at pH 4.

The deselenization reaction is done using TCEP in the presence of DTT.

Angew. Chem. Int. Ed. 2016, 55, 992 –995;

https://doi.org/10.1002/anie.201509378

Org. Lett. 2020, 22, 17, 6863–6867;

https://doi.org/10.1021/acs.orglett.0c02401

Sez can also be deprotected using Cu(II) salts:

J. Org. Chem. 2020, 85, 3, 1425–1433;

https://doi.org/10.1021/acs.joc.9b02388

J. Org. Chem. 2020, 85, 3, 1731–1739;

https://doi.org/10.1021/acs.joc.9b02644

SIZE

PRICE

5G

EUR 1530

1G

EUR 428

500MG

EUR 275

250MG

EUR 153

Send an
enquiry

Product enquiry

Bapeks Ltd.

Rupnicu 4, Nordic Industrial Park

Olaine, LV-2114

Latvia / EU

VAT Reg.# LV40003006842


@2021 Bapeks Ltd. All rights reserved.